Measurement of cerebrovascular reactivity using BOLD-MRI combined with precise controlled changes in carbon dioxide. Is this a new brain stress test?

TECHNOLOGICAL INNOVATIONS AWARD

Lakshmikumar Venkat Raghavan
University Health Network

Project Information

In our project we have a shown that the precise targeting of CO2 in combination with BOLD-MRI can be used as a non-invasive “brain stress test” to identify patients at risk for stroke. This technique can be adopted as a routine clinical test in the diagnosis, treatment and prognosis of patients who are at risk of stroke and those with suspected cerebral blood flow abnormalities.”

Cerebrovascular reactivity (CVR), defined as a change in cerebral blood flow in response to a vasoactive stimulus, reflects the vascular reserve capacity of cerebral vessels. Impaired CVR has shown to be an important prognostic marker for stroke. However, no CVR method has been widely adopted to assess the risk for stroke and for clinical management. This project developed a non-invasive method of mapping CVR using a precise targeting of CO2 and Blood oxygen level dependent (BOLD) MRI to identify patients at risk for stroke and to monitor the effect of treatments. In an innovative use of existing techniques, this study showed that the precise targeting of CO2 in combination with BOLD-MRI, provide a feasible, non-invasive and reproducible measure of CVR. This combined technique may be complementary in identifying patients with poor cerebrovascular reserve at risk for stroke and thus constitute a “Brain Stress Test”. This technique can be adapted for routine clinical test in the diagnosis, treatment and prognosis of patients who are at risk of stroke and those with suspected cerebral blood flow abnormalities. This test stands to improve patient care and lower the burden of care on our hospital system.

Themes & Abstracts

Search

Generic selectors
Exact matches only
Search in title
Search in content
Search in posts
Search in pages

CONTACT US

We're not around right now. But you can send us an email and we'll get back to you, asap.

Sending

©2019 IFPOC - The Innovation Fund Provincial Oversight Committee - created by Techna

Log in with your credentials

Forgot your details?

Facetime for Windows