SPECIALTY AND TITLE

CIHR-GSK Chair in Paediatric Clinical Pharmacology

HOSPITAL AFFILIATIONS

Children’s Hospital, London Health Sciences Centre

UNIVERSITY AFFILIATIONS

University of Western Ontario

AREA OF RESEARCH

We have studied drug safety and efficacy issues in children across a broad number of therapeutic classes. This was has included basic and mechanistic work as well as undertaking pharmacokinetic and pharmacodynamic studies, a relevant example being the first and largest study exploring the use of ketamine and propofol for safe and effective sedation in Paediatric Emergency Medicine. In the laboratory we have conducted innovative research to develop novel strategies to prevent drug-induced renal injury during chemotherapy and serious drug-induced skin disease such as Stevens-Johnson Syndrome. We have used this work to develop a unifying hypothesis for drug hypersensitivity in children.

MAJOR CONTRIBUTIONS TO SCIENCE AND/OR HEALTH CARE DELIVERY

A project on detection, prevention, and management of mood disorders and trauma following a cardiac event in men. We have tested the feasibility and acceptabilty of the stepped care program and awaiting scaling up at the Montfort Hospital – we were hindered by the COVID pandemic

A telehealth stepped care model for anxiety and depression for the francophone minority in Ontario will start in August 2023