SPECIALTY AND TITLE

Cardiovascular Surgery, Professor Emeritus and Senior Scientist Emeritus

HOSPITAL AFFILIATIONS

Toronto General Hospital – University Health Network

UNIVERSITY AFFILIATIONS

University of Toronto

AREA OF RESEARCH

New techniques of cardiac surgery: our studies on cardioplegic protection led to a series of clinical trials which established many of the currently employed techniques.
As Chair of the Cardiothoracic Surgery Clinical Trials Network, we are performing a series of multi-national trials to evaluate new methods to improve cardiac surgery outcomes.
Regenerating injured hearts: we discovered that the implantation of stem cells prevented heart failure after coronary occlusion. The initial animal studies contributed to the rationale supporting extensive clinical trials of stem cell therapy in Toronto and worldwide.

MAJOR CONTRIBUTIONS TO SCIENCE AND/OR HEALTH CARE DELIVER

Stem cell therapy to restore function after coronary occlusion: Circulation 1999;100:247.

Rejuvenation of aged hearts with tissue engineered constructs: JACC 2012;60:2237

Rejuvenation of aged hearts by bone marrow transplantation: EHJ 2013;34:1157

Stem cells during CABG: JTCVS 2016;152:1582; Stem cells on LVAD: JAMA 2019;321:1176

MVR vs MVr for MR: NEJM 2016;374:344; Rate vs rhythm treatment for PO AFib: NEJM 2016;374:1911; Embolic protection during SAVR JAMA 2017;318:536; Tricuspid repair during MVr NEJM 2022;386:327

Mentoring two generations of cardiac surgical scientists